Lithium (Enzymatic) Assay (Liquid Stable)
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Product Features
Diazyme’s enzymatic liquid stable lithium assay provides a convenient, non-caustic low cost alternative to expensive ISE and highly caustic alkaline lithium methods. Diazyme’s enzymatic lithium assay demonstrates an excellent correlation with the ISE methods and offers excellent precision (%CV <5%) and demonstrates no significant interference from all tested endogenous ions as well as ascorbic acid (5.0 mM), triglycerides (250 mg/dL), and bilirubin (45 mg/dL).
Assay Principle
The Diazyme enzymatic Lithium assay is based on a lithium sensitive enzyme whose activity is lithium concentration dependent. The enzyme, a phosphatase, converts its substrate adenosine biphosphate (PAP) to hypoxanthine through a coupled enzymatic reactions to generate uric acid and hydrogen peroxide (H2O2). H2O2 generated is then quantified by a Trinder reaction.
Intended use
For the quantitative in vitro determination of lithium in serum samples. Serum levels of lithium are monitored when patients received therapeutic lithium for treatment of diseases such as bipolar disorder (manic depressive psychosis).
Product Catalog Number Packaging Method/Format
Kit (200 Tests) DZ116B-K R1: 2 x 20 mL
R2: 2 x 10 mL
 Enzymatic/Kinetic
Liquid stable
Calibrator DZ116A-Cal 3 x 3 mL  
Control DZ116A-Con 2 x 3 mL