Diazyme Laboratories is a Division of General Atomics headquartered in La Jolla, California. Diazyme Laboratories uses its platform enzyme technologies including enzyme cycling, Substrate-Trapping-Enzyme (STE), and Allosteric Enzyme Coupled ImminoAssay (AECIA), to develop low cost and uniform diagnostic products for clinical and research use. Diazyme’s focus is to develop enzyme based diagnostic reagents for most automated chemistry analyzers. Diazyme’s products include diagnostic blood tests for liver disease, cardiac markers, diabetes and electrolytes.

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Management

Chong Yuan, Ph.D. – Managing Director
Dr. Yuan, a leading enzymologist, is the managing director and co-founder of Diazyme Laboratories. He is also the sole inventor of the three listed U.S. patents covering the entire Substrate-Trapping-Enzyme technology.

Scientific Advisory Board

Members of the Diazyme Scientific Advisory Board are well known leaders in the scientific research community and clinical practice.

Gordon Chang, M.D.
Dr. Chang has been practicing internal medicine and non-invasive cardiology in San Jose since 1977. He is well read and has a keen interest in biotechnology. Dr. Chang is a member of electrocardiogram and echocardiogram panels for Alexian Brothers Hospital (Regional Medical Center of San Jose). He is also a member of the medical committee for selecting new drugs into the hospital formulary.

Donald W. Jacobsen, Ph.D.
Dr. Jacobsen is a member of the Professional Staff and Director of the Laboratory for Homocysteine Research in the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation. He is also a CCF Professor of Chemistry and CCF Professor of Biology at Cleveland State University (CCF). Dr. Jacobson is an internationally recognized leader in the clinical study of homocysteine and its relationship to cardiovascular disease. Dr. Jacobson is laboratory is focusing on understanding the mechanism by which homocysteine causes vascular injury. Dr. Jacobson is a member of the American Heart Associations' Scientific Council for Arteriosclerosis. He has published more than 100 scientific articles in top international journals on homocysteine and related subjects.

Richard D. Kolodner, Ph.D.
Dr. Kolodner, a member of the National Academy of Sciences, is head of the Laboratory of Cancer Genetics at the Ludwig Institute for cancer research, San Diego Branch. Dr. Kolodner is a Professor, at the Department of Medicine and Department of Cellular and Molecular Medicine, and Member of the Cancer Center at the University of California, School of Medicine. Prior to moving to San Diego, he was a full Professor in the Department of Biological Chemistry at the Harvard Medical School and the Dana-Farber Cancer Institute. He served as Head of the Laboratory of Molecular Genetics and Head of the Laboratory of X-Ray Crystallography. He has also served a three-year term as Chair of the Division of Cellular and Molecular Biology at the Dana-Farber Cancer Institute.

Dr. Kolodner is an Associate Editor of both Cell and Cancer Research and serves on the editorial board of Cellular and Molecular Biology. Dr. Kolodner has authored or co-authored more than 170 scientific publications. Honors and awards include an American Cancer Society Junior Faculty Research Award, 1981; an American Cancer Society Faculty Research Award, 1984; a National Institutes of Health MERIT Award, 1992; a Sandoz Special Scientific Achievement Award, 1994, and the 1996 Charles S. Mott Prize from the General Motors Cancer Research Foundation. Dr. Kolodner was also named the Charles A. Dana Investigator at the Dana-Farber Cancer Institute in 1996.

Michael Melnick, Ph.D.
Dr. Melnick is a Stanford and Harvard educated molecular biologist and a leading scientist in cell signaling, providing significant contribution to the field while he was a staff scientist at New England Biolabs. He is currently serving as a director of business development for Cell Signaling Technology, Inc. Dr. Melnick has extensive experience in both molecular biology and assay development in industrial settings. His pioneering research in enzyme discovery using microbial DNA libraries has opened a new avenue for the diversity of biotechnology applications. Dr. Melnick has published numerous scientific papers in the top journals of the field.